Pub chain Marstons is set to cut 2,150 jobs due to the impact of the new coronavirus restrictions across hospitality.
The cuts will impact workers currently on furlough support.
The firm has said it will cut 2,150 jobs and will also launch a further 'cost-cutting plan' by the end of the year.
Bosses at the chain blame the government's new Covid restrictions in the hospitality sector for 'undermining consumer confidence and creating uncertainty'.
CEO Ralph Findlay said the restrictions have caused 'significant challenges' to the business.
"The additional restrictions which have been applied across the UK most recently present significant challenges to us and will make business more difficult for a period of time", he said.
"I very much regret that the consequence of this is that the jobs of around 2,150 of our colleagues will be impacted, but it is an inevitable consequence of the limitations placed upon our business.
"We will be looking at our cost base further in the coming weeks."
Under new measures, a 10pm curfew has been placed on all bars, restaurants and hospitality venues.
In high-risk, or 'Tier 3', areas such as Liverpool, sites not serving food must close.
In Scotland, where Marston's has 21 sites, the government has imposed a raft of further restrictions including closures in some areas and a 6pm curfew elsewhere.
A spokesperson for the chain said: "The introduction of these further restrictions and guidance affecting pubs is hugely disappointing in view of a lack of clear evidence tying pubs to the recent increase in infection levels, and our own data which suggests that pubs are effective in minimising risks."
Details of the job cuts at Marston's comes as its annual results showed pub sales tumbled 34% to £515 million in the year to October 3, impacted heavily by the lockdown earlier this year.
Since pubs reopened in July, like-for-like pub sales were 10% lower over the 13-week period, helped by the Government's Eat Out to Help Out meal discount scheme in August.
Brewery sales were 22% lower over the year at £306 million, though sales in retailers and off-licences lifted 23% as pubs were forced to close.
Marston's announced a deal in May to merge with Carlsberg's UK arm to form a joint venture worth around £780 million.
The tie-up will create the Carlsberg Marston's Brewing Company and is set to complete at the end of this month.
The chain has more than 25 pubs across the Greater Manchester region.
