Ole Gunnar Solskjaer has opted for a 3-5-2 formation as his Manchester United side seek to overcome the odds against Paris Saint-Germain tonight.
Eric Bailly comes into join Victor Lindelof and Chris Smalling at the back.
Scott McTominay continues at the base of midfield with Fred joining Andreas Pereira in the middle of the park.
Romelu Lukaku, who has four goals in his last two appearances, partners Marcus Rashford up front.
Diogo Dalot, who impressed coming off the bench against Southampton on Saturday, is again named among the subs.
Four academy products in James Garner, Angel Gomes, Tahith Chong and Mason Greenwood are named on the bench.
United arrive in Paris looking to overturn a 2-0 defeat in the first leg of the tie in Manchester earlier this month.
PSG vs Man Utd starting line-ups
Man Utd XI: De Gea, Young, Bailly, Smalling, Lindelof, Shaw, McTominay, Fred, Pereira, Rashford, Lukaku
Subs: Romero, Dalot, Rojo, Garner, Gomes, Chong, Greenwood
PSG XI: Buffon, Kehrer, Thiago Silva, Kimpembe, Bernat, Verratti, Marquinhos, Dani Alves, Draxler, Di María, Mbappé
Subs: Areola, Paredes, Meunier, Choupo-Moting, Kurzawa, Dagba, Cavani
