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The Guardian - UK
The Guardian - UK
World

Prozac is not to blame

Anthony Browne's article 'Spiral of violence blamed on Prozac' (News, last week) contains inaccuracies. A US Food and Drug Administration advisory board agreed: 'There is no credible evidence of a causal link between the use of antidepressant drugs, including Prozac, and suicidality or violent behaviour.'

The safety profile of Prozac has been well documented in clinical trials in which more than 12,000 patients participated and throughout 12 years of experience in 35 million patients worldwide.

In fact the use of antidepressants appears to protect against aggressive behaviour. A study published in December 1997 by Emil Coccaro, professor and director of the clinical neuroscience research unit at Allegheny College in Philadelphia, suggested Prozac actually reduces aggressive behaviour.

The ruling in the Connecticut case that your article cites is difficult to square with the undisputed facts that the defendant carefully planned his actions. In at least 77 other cases, criminal defendants have failed in their efforts to use Prozac as a means to escape culpability for their actions.
Dr A. Simpson
Eli Lilly and Company Ltd
Basingstoke

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