Manchester City moved back to the top of the Premier League but lost Kevin de Bruyne to injury in a 1-0 victory over Bournemouth at the Vitality Stadium.
In a typically frenetic north London derby, Pierre-Emerick Aubameyang's last-minute penalty was saved as Arsenal settled for a 1-1 draw at Tottenham.
The stalemate saw Tottenham slip 10 points behind City while Arsenal were knocked out of the top four as a resurgent Manchester United came from a goal down to claim a 3-2 win over Southampton.
Elsewhere, Brighton clinched their first league win of the year as they edged out rock-bottom Huddersfield 1-0 at the Amex Stadium, moving the Seagulls five points clear of the relegation zone.
Burnley suffered their second defeat in a week as Phil Bardsley's own goal plus efforts from Michy Batshuayi and Wilfried Zaha helped Crystal Palace clinch a 3-1 win at Turf Moor.
Quickfire first-half strikes from Diogo Jota and Raul Jimenez ushered Wolves to a 2-0 triumph over Cardiff at Molineux.
Re-live the action below:
TEAM NEWS: BOURNEMOUTH VS MANCHESTER CITY
TEAM NEWS: BRIGHTON VS HUDDERSFIELD TOWN
TEAM NEWS: BURNLEY VS CRYSTAL PALACE
TEAM NEWS: MANCHESTER UNITED VS SOUTHAMPTON
TEAM NEWS: WOLVES VS CARDIFF CITY



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