The international break is all but over and minds can turn back to the bread and butter of club football, with Cristiano Ronaldo's second coming at Manchester United the Premier League main course.
Ronaldo returned from Portugal duty early as he geared up to face Newcastle United at Old Trafford on Saturday afternoon, when Ole Gunnar Solskjaer will face a dilemma over whether or not to play him from the start.
You can guarantee that he'll be fit, firing and champing at the bit ready for action as club duties resume, but other players aren't so lucky.
Here, we've taken a look at the always reliable PremierInjuries.com for the latest on the availability of top-flight players, with a more detailed outlook on their issues available over on their website.
Information correct at time of writing
Arsenal
Injured/absent: Granit Xhaka (suspended/Covid-19 protocols)
Doubtful: Sead Kolasinac (knock), Mohamed Elneny (muscle)
Returning: Ben White, Thomas Partey, Eddie Nketiah, Nicolas Pepe (all back in training)
Aston Villa
Injured/absent: Emi Buendia, Emi Martinez (both quarantine), Bertrand Traore (thigh), Trezeguet, Keinan Davis (both knee).
Doubtful: Ezri Konsa (knee)
Returning: Jacob Ramsey, John McGinn (both Covid-19 protocols), Leon Bailey, Morgan Sanson (both back in training)
Brentford
Injured/absent: Mads Sorensen (knee), Josh Dasilva (groin)
Returning: Frank Onyeka (Covid-19 protocols)
Brighton
Injured/absent: Dan Burn (knee), Tariq Lamptey (thigh), Kjell Scherpen (ankle)
Returning: Solly March (thigh)
Burnley
Injured/absent: Connor Roberts (groin), Dale Stephens (ankle), Kevin Long (calf)
Doubtful: Nathan Collins (knock)
Chelsea
Injured/absent: Reece James (suspended), Thiago Silva (FIFA ban)
Doubtful: N'Golo Kante (ankle), Romelu Lukaku (thigh)
Crystal Palace
Injured/absent: Michael Olise (back), Eberechi Eze (calf), Nathan Ferguson (Achilles)
Doubtful: Luka Milivojevic (knock)
Everton
Injured/absent: Seamus Coleman (thigh), Fabian Delph (shoulder), James Rodriguez (other)
Doubtful: Yerry Mina (knock), Dominic Calvert-Lewin (quad)
Returning: Ben Godfrey (Covid-19 protocols)
Leeds
Injured/absent: Robin Koch (groin), Raphinha (FIFA ban)
Returning: Mateusz Klich, Junior Firpo (Covid-19 protocols)
Leicester
Injured/absent: Ayoze Perez (suspended), James Justin (knee), Wesley Fofana (medial ligament), Nampalys Mendy (groin)
Doubtful: Ricardo Pereira (hamstring), Jannik Vestergaard (knee), Jonny Evans (ankle)
Returning: Ryan Bertrand (Covid-19 protocols)
Liverpool
Injured/absent: Roberto Firmino (hamstring), Fabinho, Alisson (FIFA ban)
Doubtful: James Milner (calf), Takumi Minamino (thigh), Neco Williams (ankle), Harvey Elliott (knock)
Manchester City
Injured/absent: Zack Steffen (Covic-19 protocols), Benjamin Mendy (suspended), Gabriel Jesus and Ederson (FIFA ban)
Doubtful: Liam Delap (other)
Returning: Kevin De Bruyne, Phil Foden, Aymeric Laporte (all set to return to training)
Manchester United
Injured/absent: Marcus Rashford (shoulder), Phil Jones (knee), Fred (FIFA ban)
Doubtful: Scott McTominay (groin), Alex Telles (ankle),
Returning: Jadon Sancho (other), Dean Henderson (Covid-19)
Newcastle
Injured/absent: Martin Dubravka (ankle), Jonjo Shelvey (calf), Ryan Fraser (ankle), Elliott Anderson (groin), Miguel Almiron (FIFA ban)
Doubtful: Isaac Hayden (knee), Paul Dummett (calf), Callum Wilson (thigh)
Returning: Karl Darlow (Covid-19)
Norwich
Injured/absent: Sam Byram (thigh), Bali Mumba (knee)
Doubtful: Christos Tzolis (calf), Przemyslaw Placheta, Jordan Hugill (both Covid-19)
Southampton
Injured/absent: Will Smallbone (knee)
Doubtful: Shane Long (Covid-19), Stuart Armstrong (calf)
Tottenham
Injured/absent: Cristian Romero, Giovani Lo Celso, Davinson Sanchez (all quarantine), Cameron Carter-Vickers (ankle), Tanguy Ndombele (other)
Doubtful: Ryan Sessegnon (knock), Heung-min Son (calf), Steven Bergwijn (ankle)
Returning: Joe Rodon (other)
Watford
Injured/absent: Joao Pedro (knee), Franciso Sierralta (FIFA ban)
Doubtful: Ben Foster (thigh), Dan Gosling (ill)
West Ham
Injured/absent: Winston Reid (knee)
Doubtful: Kurt Zouma (personal reasons)
Wolves
Injured/absent: Pedro Neto, Jonny Otto (both knee), Hugo Bueno (thigh), Raul Jimenez (FIFA ban)
