Jose Mourinho will return to Manchester United looking to keep his Tottenham Hotspur team's momentum from their three straight wins in the early weeks of his reign.
Spurs have seen off West Ham, Olympiacos and Bournemouth so far under their new head coach but they face their sternest test with the visit to Old Trafford.
Mourinho's key decisions come at left-back and in midfield.
The Tottenham boss must decide whether to restore Danny Rose at left-back or stick with Jan Vertonghen in the role, with the Belgian able to step inside to make a back three in keeping with Mourinho's system.
In midfield it is likely to be a tussle between Harry Winks and Tanguy Ndombele over who plays alongside Eric Dier. Ndombele replaced Winks for the win against Bournemouth but the England international will be the fresher man.
Mourinho's other big decision will be whether to take goalscorer from Saturday Moussa Sissoko out of the team to replace him with Lucas Moura.
The Brazilian certainly knows how to score at Old Trafford, as he did against Mourinho's United side twice last season.
Here is the Spurs team we reckon Mourinho will pick to take on his old side: (4-2-3-1) Gazzaniga; Aurier, Sanchez, Alderweireld, Vertonghen; Dier, Winks; Lucas, Alli, Son; Kane.
The match will be streamed live for the first time on Amazon and fans can watch it using a free trial here.
