Manchester United's quest for European glory begins on Tuesday evening as they take on last season's Champions League finalists Paris Saint-Germain.
United have been handed a tough draw, with the French champions, RB Leipzig and Istanbul Basaksehir all bidding to qualify from Group H.
Ole Gunnar Solskjaer's side go into the game on a high after picking up a vital 4-1 win against Newcastle at the weekend.
Goals from captain Harry Maguire, Bruno Fernandes, Aaron Wan-Bissaka and Marcus Rashford sealed the victory and made it perfect preparation for their trip to Paris.
But Solskjaer will be without several of his first team stars for the clash, with captain Harry Maguire out injured and Bruno Fernandes to take the armband.
Maguire sustained a small muscle tear at St James' Park, but confirmed that he was working on his recovery ahead of the Chelsea clash.
"Disappointed to miss tomorrow’s game through injury… I’ll be working hard to get back fit ASAP. The start of our #ChampionsLeague campaign. #MUFC," he wrote on Instagram.
Solskjaer was also hopeful that Maguire will be fit again to take on the Blues.
"Hopefully Harry [Maguire], Eric [Bailly]and Mason [Greenwood] as well, but not sure about that.
"We hope Harry will be fit for the weekend, we’re not sure but we hope so."
Edinson Cavani will also miss the game with the striker not travelling to France with his teammates, and Solskjaer admitted that the Uruguayan needs more training before he can be considered.
"We hope the players won’t be away for too long. Edinson [Cavani] needs a few more days training before we can maybe think about the weekend," the United boss said.
Mason Greenwood is also out, but could return against Chelsea.
"I can’t declare medical stuff, can I?" Solskjaer said before the game. "We hope it’s just a niggle and we don’t want to take any chances with him and hopefully at the weekend it’ll be fine again."
Anthony Martial returns to the squad for the Champions League after serving the first of his three-match domestic ban for the red card he received against Tottenham.
Martial was shown a straight red card after VAR deemed his slap on Erik Lamela as violent conduct.
The French international will miss United's upcoming games against Chelsea and Arsenal, but can play in the Champions League.
With that in mind, here's the predicted line-ups for United's two upcoming clashes against PSG and Chelsea.
Man United XI vs PSG: De Gea; Tuanzebe, Lindelof, Shaw; Wan-Bissaka, McTominay, Fred, Telles; Fernandes; Rashford, Martial.
Man United XI vs Chelsea: De Gea; Wan-Bissaka, Maguire, Lindelof, Shaw; Fred, McTominay, Pogba, Fernandes; Greenwood, Rashford.