Portugal and Mauritius have been removed from England's travel ban red list.
This means Brits flying back no longer have to quarantine when they come home, opening the way for tourists to head there for holidays.
The Department for Transport said Portugal has been removed from the red list, including Madeira and the Azores, following evidence that showed the risk of importing a variant "had reduced".
A statement added: "Portugal has put steps in place to mitigate the risk from its links with countries where variants have become a concern, and now has genomic surveillance in place."
It means that passengers arriving into England from these destinations from Friday morning will no longer be required to quarantine in a Government-approved hotel.
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The flight and maritime ban from Portugal (including Madeira and the Azores) is also being removed.
As well as announcing changes for Portugal, the Government said Ethiopia, Oman, Somalia and Qatar had been added to the red list to protect against new Covid-19 variants.
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The change will come into affect from 4am on Friday, meaning British and Irish citizens or residents arriving in England from those countries after that time will have to quarantine in a Government-approved hotel for 10 days, and any other visitors will be refused entry.
A ban on commercial and private planes travelling from Oman, Ethiopia and Qatar will also come into force on Friday to reduce the risk of importing "variants of concern".
