It is second versus first in Group I as England travel to Poland to maintain their undefeated record in the qualifying stages and look to go one step closer to secure their place in Qatar as early as possible.
England are the favourites at 4/7 while Poland are 5/1 longshots with Grosvenor Sport while a draw is 11/4.
The Three Lions will be looking top maintain their 100% record in qualifying and extend the gap against their hosts to eight points as we approach the second-half of qualifying.
Southgate's side has an almost impeccable record winning all five matches so far, scoring 17 and conceding only once - courtesy of Polish international and Brighton & Hove Albion player Jakub Moder.
They will have to be on their toes however as Poland go into this game scoring 11 goals already in this international break - including seven against San Marino.
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Team stats
Gareth Southgate is undefeated as England manager in the World Cup qualifying stage, dropping points on two occasions against Scotland in 2017 and a 0-0 draw against Slovenia.
The former Middlesbrough man averages 2.71 points-per-match and has seen 34 goals at this stage of the competition as England manager.
Player stats
Robert Lewandowski has scored three goals in his last two matches for his country while fellow striker Adam Buksa bagged a hat-trick against San Marino.
Harry Kane averages a goal-a-game in the current qualifying period but Lewandowski has scored two more goals than Kane.
H2H
This will be the 21st meeting between the two countries with Poland only ever beating England once in their first meeting back in 1973.
Since then England have gone on to draw seven times and beating the Eagles 12 times.