Piers Morgan and Susanna Reid will be replaced on Good Morning Britain from Monday for a week.
The ITV presenting duo are taking their usual half-term break with Kate Garraway and Ben Shepherd set to stand-in.
Kate and Ben, who are usually the main hosts on a Thursday and Friday, will take on Piers and Susanna's Monday to Wednesday slot.
As they finished Friday's GMB, Kate said: "Ben and I are back at six on Monday."
Kate and Ben often share the presenting role Adil Ray, Ranvir Singh, Sean Fletcher and Charlotte Hawkins in various shake-ups of the panel throughout the year.
Kate, 53, returned to GMB last week after two weeks as she explained she took annual leave after "feeling unwell."
"It's lovely to be back," she said leading to Ben mentioning: "A lot of people have been very concerned."
"I've taken some time off," Kate explained. "On ITV they've very kindly given me some time off. I haven't been feeling very well - I think it might be one of those things where chickens come home to roost after a long year that we've all had.
"I just took some holiday leave - at home, I know holidays are controversial - within the four walls of my home. I had a lot of sleep and a bit of medicine and feeling much better, thank you."
