PITTSBURGH _ Gabriel Landeskog's goal 22 seconds into overtime gave Colorado a 4-3 win Monday night, handing the Penguins their first loss of the young season.
Landeskog knocked a loose puck out of midair and tipped it past Marc-Andre Fleury for the goal.
Both teams took advantage of their power-play opportunities, each netting two goals with the man advantage _ including one apiece in the third period.
Landeskog scored on the power play at 13:28 of the third period after Trevor Daley had given the Penguins the lead earlier in the period.
Daley's power-play goal on blast from the point at 9:12 of the third period put the Penguins ahead, but only for a couple of minutes.
Earlier in the game, both teams had what would have been go-ahead goals called off by video review. The Avalanche lost one because a puck was kicked in midway through the second period, and the Penguins had an Evgeni Malkin score wiped away because officials ruled Malkin interfered with Colorado goalie Calvin Pickard before he scored.
A few minutes before Malkin's disallowed goal, the Penguins' penalty killers kept the game tied midway through the third period. The Avalanche had 50 seconds of a five-on-three _ their second such advantage of the game _ but couldn't find the back of the net. They had several shots right in front of Fleury, but couldn't poke one past him.
Neither team scored in the second period after a first period that saw four combined goals.
The Penguins jumped out to a 2-0 lead midway through the first period with two goals in 39 seconds.
Phil Kessel got them on the board with a power-play goal, his second of the season, at 8:57 of the opening period. Kessel's goal came on a shot from the right circle and beat Colorado goalie Calvin Pickard five-hole.
Matt Cullen doubled the lead less than a minute later. He and Chris Kunitz both had a shot at the puck right in front of Pickard, and Cullen whacked it in on the third try for his first goal of the season.
The lead wouldn't even last to the first intermission, though, as back-to-back Penguins' penalties jump-started the Avalanche offense.
With Nick Bonino in the box for tripping and Kunitz for hooking, the Avalanche capitalized with a five-on-three goal from former Penguin Jarome Iginla. It marked the second consecutive game the Penguins have given up a five-on-three goal.
Just 1:23 later, Patrick Wiercioch tied the score for the Avalanche on a shot from the point that found its way past a screen Fleury.
The Penguins return to action Tuesday night in their first road game of the season against Montreal.
