PDRN — or PolyDeoxyRiboNucleotide — first gained widespread traction in South Korea and Italy where it became celebrated for its remarkable regenerative and skin-repairing properties.
Since then, the so-called miracle molecule has become one of the world’s fastest-growing treatment and product categories, with fans from Jennifer Aniston to Kim Kardashian and Hailey Bieber singing the praises of its various iterations.
Israeli facial aesthetician Keren Bartov, whose Notting Hill clinic has become a place of pilgrimage for the skin-obsessed, says PDRN is now her most-requested treatment.
“People are moving away from the overfilled look," agrees Dr Jennifer Owens of The Glow Clinic. “Instead they’re seeking treatments that regenerate and enhance skin health — ones that feel more natural and restorative. The idea of something derived from DNA fragments can seem especially appealing within that context.”
Yes, PDRN comes from salmon sperm…
Derived from the DNA of salmon (and sometimes trout), PDRN is remarkably compatible with human skin. In its refined form, it is praised by many of the world’s most respected aesthetic and skincare professionals for its ability to stimulate cell repair, boost collagen, and calm inflammation, working deep within the skin at a cellular level to reset and rejuvenate complexions from within.
As such, this so-called miracle molecule works to heal and enhance rather than alter, aligning neatly with our evolving preference for treatments that enhance skin health and longevity.
Part of the polynucleotide family
PDRN belongs to a wider family of bio-compatible skin-regenerative molecules called polynucleotides — long chains of DNA fragments that act as cellular messengers, nudging skin to behave as if it were younger.
In doing so, polynucleotides can trigger fibroblasts to produce more collagen and elastin, improve hydration and repair microdamage, making them the perfect solution for tired or stressed complexions.
PDRN is a specific, highly refined type of polynucleotide known for its wound-healing and anti-inflammatory properties. “What makes PDRN stand out is its regenerative approach and flexibility,” says Dr Owens. “It can even be used in delicate areas such as under the eyes, where hyaluronic acid injectables can be tricky. And it works with your own biology rather than simply filling or replacing volume.”
From medicine to maintenance
Before making its way into cosmetic dermatology and product formulation, PDRN has had a relatively long history of medical use, “particularly in Italy and South Korea, where it has been harnessed to treat serious skin injuries, burns, and inflammatory conditions,” explains Bartov.
“Over time, its cosmetic potential became clear — especially in reviving tired, irritated, or uneven skin. Its subsequent surge in popularity comes down to safety, its compatibility with most skin types, and the ability to deliver visible results fast,” she adds.
How to try it...
In clinics, PDRN is typically delivered via injectable “skin boosters,” applied topically after micro-needling or resurfacing and rejuvenation treatments like Tixel.
Results are subtle but can be thrillingly transformative — think stronger barrier function, refined texture and pores, and that longed-for radiant glow. “Most patients see results within 2–3 weeks,” says Bartov, “often with smoother, plumper and more radiant skin although in some cases, especially following in-clinic treatment, results can be seen after a single session.”
As with any injectable treatment, safety comes down to practitioner expertise, but adverse reactions are rare thanks to the molecule's close compatibility with human DNA. Dr Owens is also quick to flag that not all PDRN products are created equal.
“Some may not have undergone the same level of testing or quality control, which can lead to wasted time and money if results don't live up to expectations.”
As with any treatment, a thorough consultation will help you work out if this is a suitable treatment for your skin and concerns. “It’s important not to view PDRN as a cure-all,” says Dr Owens.
“It’s a fantastic tool, but works best as part of a broader, balanced plan that might also include treatments like muscle-relaxing injections, filler, or laser, depending on your goals.”
