People living in Oxford are being urged to reduce their travel and surge testing is being brought into the city to tackle soaring Covid cases.
Mass testing for people under 30s is also being rolled out.
As part of the new measures, which will come into place on Monday, people living in Oxford will also be urged to get the Covid jab.
Similar measures have already been introduced across the North West, and Bedford and Birmingham.
The infection rate in Oxford, which is the 14th highest in England, will be regularly reviewed to determine if support is still needed.
Health Minister Lord Bethell said: “Working closely with the local authority, we are providing a strengthened package of support in Oxford.
"We know this approach can work and it is based on our successful partnerships with other areas where there was a significant rise in cases.
"This extra support is intended to help slow the rate of infection as restrictions are lifted, allowing more people to get double jabbed.
“The most important thing that people in this area can do is take a test if they are offered to do so, practise hands, face, space and fresh air, and get their jab - the vaccine is building a wall of protection around us all.”
The news comes as a total of 35,707 people have tested positive to coronavirus in the UK in the last 24 hours which is the highest number of cases recorded in the third wave and since January 23.
On Monday Boris Johnson announced face masks, social distancing, those QR codes and ordering at the bar in pubs will no longer be a legal requirement in England from that date.
Full-size stadium gigs and theatre shows will also be able to restart with no social distancing restrictions.
Masks won’t even be legally required in hospitals and care homes - and won’t be specifically advised on public transport.
Despite relaxing the rules Mr Johnson admitted the pandemic is "far from over", adding "It certainly won't be over by the 19th".
He even admitted daily cases could hit 50,000 a day by then - and the link with deaths, while weakened, is not entirely severed.
