A total of 301 Covid-19 admissions were recorded by hospitals in London on December 20, NHS England has said, marking a 78 per cent week-on-week.
The figure is also the highest number of admissions for a single day since January 6, when 977 patients were admitted to London hospitals with Covid.
Hospital admissions in England for people with confirmed or suspected Omicron has shot up to 195 and the number of deaths in England of people with the variant has risen to 18, the UK Health Security Agency said.
Across England, 1,061 hospital admissions were recorded on December 20, up 34% week-on-week and the highest number for a single day since February 19.
The second-wave peak was 4,134 admissions on January 12.
The number of Covid-19 admissions includes people admitted to hospital in the previous 24 hours who were known to have Covid-19, plus any patients diagnosed in hospital with Covid-19 in the previous 24 hours.
The dire news of rising hospitalisations comes after reports that UK Covid cases have soared by 106,122, in the biggest ever daily increase since the beginning of the pandemic.
Last Wednesday 78,610 cases were reported - meaning there has been a 30% increase over the last seven days.
Experts warn real figures are likely to be considerably higher, with Health Secretary Sajid Javid having previously pegged the number at up to 200,000 each day.
A further 140 deaths from all have also been reported over the past 24 hours.
As the Omicron variant is continuing to to run rampant across the country, concerns grow about whether the health service will be equipped to cope with a third wave.
Scientists have warned that if stricter containment measures aren't implemented quickly, the strain could quickly run rampant and collapse the NHS.
The Omicron variant has only been detected in the UK for less than a month and there are still many uncertainties.
Brits who catch Omicron are less likely to become severely ill than those infected with the Delta variant, according to the UK Health Security Agency.
The organisation, which replaced Public Health England, has studied cases in Britain and now believes people who catch the new strain will probably have less serious symptoms.
Initial research and studies from its country of origin, South Africa, suggest it's a "milder" strain compared to Delta or the original Wuhan strain, but scientists have warned Brits not to think it is harmless.
Despite rising cases, Boris Johnson promised he will not introduce further restrictions in England before Christmas, although he refused to rule out extra measures after December 25.
