Tottenham have left full-backs Danny Rose and Serge Aurier at home as they travel to face Olympiacos in their Champions League opener on Wednesday night.
Neither player was selected for the trip to Greece after starting Saturday's 4-0 Premier League win over Crystal Palace, with Mauricio Pochettino set to make changes at the Karaiskakis Stadium.
Kyle Walker-Peters and Ben Davies are expected to be restored to the first XI against Olympiacos, with Davinson Sanchez potentially set to deputise for Toby Alderweireld after injury.
Versatile defender Juan Foyth (ankle) and summer signing Giovani Lo Celso (hip) remain sidelined, while Ryan Sessegnon is not available to make his debut after suffering a setback in his recovery from a hamstring issue.
Record signing Tanguy Ndombele looks set to return to a three-man midfield, with Lucas Moura also in contention to start as Erik Lamela and Christian Eriksen likely make way.
Predicted lineups
Olympiacos XI (4-2-3-1): Sa; Elabdellaoui, Semedo, Meriah, Tsimikas; Guilherme, Bouchalakis; Podence, Valbuena, Masouras; Guerrero
Tottenham XI (4-3-3): Lloris; Walker-Peters, Sanchez, Vertonghen, Davies; Sissoko, Winks, Ndombele; Moura, Kane, Son
