With Bayern Munich and Tottenham already through to the knockout stages, as place in the Europa League is up for grabs here in a winner-takes-all encounter.
Red Star Belgrade can book their spot there with a draw, and defeated Olympiacos 3-1 in Belgrade back in October.
But the Greek side impressed in their first half against Tottenham last time out, where they raced to a 2-0 lead before Jose Mourinho’s side overturned the deficit to seal their qualification.
Here's how to follow all the action on Wednesday night...
TV channel, live stream and how to watch online
The match will be televised live on BT Sport Extra 5 via the ‘match choice’ option, and can also be streamed live online via the BT app and website, with kick-off scheduled for 8pm GMT.
You can follow all the action and analysis on Standard Sport's LIVE blog.
Prediction: Olympiacos 2-0 Red Star Belgrade
Olympiacos, with home advantage, should have enough to avenge their defeat in Belgrade and book their spot in the Europa League.
Team news
Olympiacos: Jose Sa, Elabdellaoui, Meriah, Semedo, Tsimikas, Guilherme, Camara, Bouchalakis, Daniel Podence, El Arabi, Giorgos Masouras
Subs: Benzia, Guerrero, Allain, Lovera, Papadopoulos, Torosidis, Randjelovic
Red Star Belgrade: Borjan, Gobeljic, Degenek, Milunovic, Rodic, Ivanic, Petrovic, Garcia, Marin, Vukanovic, Antonio Tomane
Subs: Popovic, Pankov, Vulic, Pavkov, Richmond Boakye, Jander, van La Parra
Referee: Daniele Orsato
