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NT posts record 594 COVID-19 cases

It's concerning that the NT has had significant escalation in COVID-19 numbers, Natasha Fyles says. (AAP)

The Northern Territory has reported another daily COVID-19 case record with 594 infections diagnosed overnight.

The figure - until 8pm on Friday is up from 412 reported the previous day.

Health Minister Natasha Fyles said the virus has spread to every region in the territory as the number of active cases grows to 1200.

"It is concerning that we have had significant escalation in the numbers but we expected this," she told reporters on Friday.

"We can still manage these numbers that we're seeing and I expect these numbers to grow over the coming days."

Meanwhile, an investigation is under way into cases in Nhulunbuy in east Arnhem Land, about 700km east of Darwin.

More than 20 infections were also detected in Alice Springs and one was detected in Tennant Creek, 510km to the north.

A territory-wide lockout of unvaccinated people aged 16 and over started on Thursday and will continue until midday on Monday when a proof of vaccination pass system will be rolled out.

It will run on the territory's check-in app and apply to most hospitality and entertainment venues.

Under the lockout, unvaccinated people can only leave their homes for medical treatment and testing, essential goods and services, and to care for a vulnerable person.

They are not permitted to go to workplaces or travel more than 30 kilometres.

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