People in NSW aged between 40 and 49 can now make a booking to receive the Pfizer COVID-19 vaccine at 25 sites around the state.
For those in that age bracket, the Pfizer vaccine has until now only been available only at the mass vaccination hub at Sydney Olympic Park.
But Premier Gladys Berejiklian says Pfizer vaccines will now be available for anyone aged between 40 and 49 at 25 sites, including 17 in regional areas.
An additional six sites for COVID-19 jabs will open next month.
"We know (vaccination) gives us an opportunity to ease any restrictions but also to think about how we reconnect with the rest of the world," Ms Berejiklian told reporters on Thursday.
"NSW wants to be as ready as possible, as soon as possible, to make sure we don't get left behind."
The NSW government is aiming to administer 60,000 vaccines a week, despite Australia's vaccine rollout lagging behind other countries.
Almost one million vaccines - 998,049 - have now been administered in NSW, including Commonwealth government-administered doses.
Ms Berejiklian appears keener to open the country's borders than Prime Minister Scott Morrison, who is sticking to a mid-2022 timeline.
The federal government has so far shied away from identifying the number of vaccinations that would allow border restrictions to ease.
But Ms Berejiklian says five million adults in NSW will need to get the jab before international borders can open - about 10 million doses in total.
She also brushed off concerns about vaccine hesitancy, saying the large majority of people keen to receive the jab should be front of mind.
"We know there's a large portion of the population very keen to get vaccinated no matter what age they are or what vaccine they're offered," the premier said.
"The biggest incentive is to lead a more normal life ... we can't be shut off from the rest of the world forever and we need to be ready for what that might mean."
Australian Medical Association president Omar Khorshid is also backing calls for the federal government to set a date to open international borders, saying a timeline would motivate Australians to get vaccinated.
Yet Ms Berejiklian admits some aspects of pandemic governance will remain indefinitely, including the use of QR codes at venues and COVID-19 testing for anyone with respiratory symptoms.
"Until the deadly consequences of COVID-19 aren't around ... we just have to accept some things we'll have to live with until literally the COVID virus isn't in its current form, and that could take years," she said.
NSW recorded zero new locally acquired COVID-19 cases in the 24 hours to 8pm on Wednesday, as well as two cases in hotel quarantine.
One COVID-19 patient in NSW is currently in intensive care.
It comes as the federal government says it will launch a media campaign encouraging older Australians to get vaccinated.
