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NSW crash driver under guard in hospital

Police had stopped pursuing the SUV before it was involved in a crash with five other vehicles. (AAP)

A man is under police guard in hospital following a crash minutes after a pursuit on Sydney's busy Parramatta Road involving five other vehicles.

It's alleged highway patrol officers tried to stop a Subaru Outback at Leichhardt just after 6.20am on Saturday when its driver was seen to disobey a red light.

The car failed to stop and a chase was initiated before being terminated shortly after due to safety concerns.

After this, the Subaru collided with a Jeep Cherokee, a Toyota Prado, a Honda Civic, a Mazda 6 and a Toyota Corolla near the intersection of Old Canterbury Road, police say.

Officers responded and assisted the occupants of the vehicles, who were treated by ambulance paramedics.

The Jeep driver, a 40-year-old man, was taken to Royal Prince Alfred Hospital for scans.

The 40-year-old man behind the wheel of the Toyota was freed from the vehicle and taken to Royal Prince Alfred Hospital in a stable condition, while a male passenger, 45, was taken to St Vincent's Hospital for scans.

The drivers of the Honda, Mazda and Toyota - aged 72, 34 and 32 respectively - were assessed at the scene.

The 35-year-old Subaru driver was arrested and taken to St George Hospital, suffering minor injuries.

He has since undergone mandatory testing and remains under guard.

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