Some members of staff at Nottingham College could go on strike over the row about the college's plans to impose new contracts.
Members of the University and College Union (UCU) at Nottingham College were balloted on industrial action, with 96 percent backing going on strike.
It comes after the union held protests over new employment contracts which they say are "unfair and undermining".
Staff said the new contracts will leave 80 percent of staff better off or paid the same, however it would leave more than 80 staff more than £1,000 worse off.
The union said members will meet early next week to discuss next steps and said if the college wanted to avoid disruption it needs to rule out the sacking of any staff and to come back to the negotiating table to address concerns over the contract changes.
Staff said the new contracts would also see them lose up to eight days’ holiday, as well as cuts to sick pay and the removal of workload protections.
UCU head of further education Andrew Harden said: "UCU members at Nottingham College have made it absolutely clear that they will not put up with these contracts being imposed on them.
"It is not acceptable for the college to try and bully people into signing away their rights and members are prepared to fight these changes.
"Nottingham College is swimming against the tide when it comes to staff pay and conditions and its refusal to address our members’ concerns meant we were left with no option but to ballot for strike action.
"We hope this incredibly strong mandate for strike action will focus the minds of those in charge at the college and we can get back to the negotiating table."
A Nottingham College spokesman said: “We are saddened that our UCU colleagues have voted to pursue strike action.
"Everybody in the college cares passionately about providing our students with the best possible education and we will continue to talk to UCU in an attempt to reach a collective agreement and avoid any strike action.
"While we respect the rights of our staff to take industrial action our priority will be to ensure we do everything we can to ensure students’ studies are not affected.
"The college will remain open as usual throughout any industrial action.”
