Northern Quarter live music institution Night & Day Café is to temporarily close its doors following the introduction of the new 10pm lockdown curfew.
Bosses at the Oldham Street venue - which has played host to the likes Arctic Monkeys, Elbow and the Manic Street Preachers - say they have taken the 'unprecedented' decision 'with deep regret'.
Most events have been rearranged for later in the year and any tickets will remain valid, although refunds are also being offered.
A statement on the Night & Day Café website reads: "It is with deep regret that in light of recent government suggestions, we have temporarily closed our doors.
"Our job here at Night & Day is to make visitors feel happy and enhanced - to welcome music lovers, drinkers, diners, bands and DJs into the venue and then later on to see them safely off home.
"The safety and comfort of our staff and guests has always been of paramount importance and this has led to this unprecedented decision.
"Things continue to change daily so we will endeavour to keep you posted as to any adjustments to events, and plans for the future here and across socials.
"Most affected events are being rescheduled for later in the year so if you already have tickets booked then these will remain valid for the rearranged date. Refunds are available from your individual points of purchase.
"Finally, thank you for all the supportive messages during these strange and demanding times; we are seeing people at their absolute best – kind, resourceful and brave.
"Stay safe, we’ll see you soon."
Last month it was announced Elbow are to play an intimate fundraising gig at the Night & Day cafe top raise cash for grassroots music venues affected by the coronavirus pandemic.
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It will take place when social distancing rules are eased and gigs are allowed again.
The live music sector is among the industries hit hardest by the lockdown.
Figures from music industry analysts, Carey & Chambers predict that without an extension to the furlough scheme, almost three in five people in employed in venues will be out of a job by the end of the year.
Employment in the live entertainment sector has fallen by 15% so far.
