Nine people were rescued and around 40 residents evacuated as a "complex" fire raged in a block of flats in North Kensington.
Twelve fire engines and around 80 firefighters fought the blaze in North Pole Road at 11.22pm on Thursday.
Firefighters rescued six trapped people from windows and balconies of the three-storey block using 13.5 metre ladders.
A further three were rescued by crews wearing breathing apparatus via an internal staircase.
Two residents were taken to hospital by the London Ambulance Service as a precaution, and there are no reports of any further injuries, the London Fire Brigade said.
Around 40 people were evacuated from the building whilst crews responded and relocated to a rest centre.
Control room operators helped give fire safety advice to residents as rescue operations were carried out.
A flat on the second floor, in a residential block of three floors, was completely destroyed by the fire.
The cause of the fire, which was under control by 12.56am, is now under investigation.
Speaking from the scene, Assistant Commissioner Pat Goulbourne said the first engines arrived at the scene within four minutes of the first 999 calls about the blaze.
He said: "Not long after arriving, firefighters recognised the complex nature of this incident and that a number of rescues would need to be carried out.
"Additional resources were requested, and eventually 12 fire engines and around 80 firefighters would be deployed to the scene.
"Thanks to the quick thinking of our crews, six people were rescued from windows and balconies by firefighters utilising their 13.5 metre ladders.
"Whilst these rescues were happening outside, a further three people were rescued via the internal staircase by crews wearing Breathing Apparatus.
"Throughout the incident, our firefighters were supported by their colleagues in the Brigade’s Control Room.
"Control officers carried out a number of Fire Survival Guidance calls with residents in the building, as crews responded outside.
"I’d like to thank our firefighters and staff for their handwork and determination in responding to this incident. I’d also like to thank our colleagues from the London Ambulance Service and Metropolitan Police Service for their support at the scene.
"The cause of this fire is now under investigation by the Brigade’s specialist fire investigators."
