No trains are running between St Pancras station and Bedford today following a rail crash which saw one person killed and 89 injured.
The incident occurred when two trains collided yesterday afternoon.
No services will run between the stations until at least Monday as emergency services continue to respond.
The crash caused severe delays on the rail network and East Midlands Railway warned of severe delays throughout Saturday.
National Rail said tickets would be accepted on alternative routes.
Planned engineering works are also affecting the route’s closure.
Police remained near the scene of the crash near Bedford overnight.
The collision left 11 people with very serious injuries, 22 seriously injured and 56 with minor injuries, according to the East of England Ambulance Service.
Multiple passengers were injured after the 4.40pm East Midlands Railway service from Corby to London St Pancras collided with the 3.50pm Nottingham to London St Pancras service on Friday.
The Ampthill Road is closed from the Interchange Retail Park roundabout to Manor Road in Kempston Hardwick.
A British Transport Police officer was standing by the road closure sign on the roundabout exit rato divert drivers.
A Rail Accidents Investigation Branch van and a Deutsche Bahn vehicle have been allowed to drive on to the closed road.
A spokesperson for National Rail said: “All lines are closed between London St Pancras International and Bedford due planned engineering works.
“Since yesterday, Friday 19 June, the emergency services have also been dealing with an incident between Luton and Bedford. No trains will run between London St Pancras International and Bedford this weekend.
“You can read more information on the engineering works via the Bedford and London St Pancras International engineering page. Trains that usually start and terminate at London St Pancras International will start and terminate at Bedford instead. East Midlands Railway will be operating a planned, amended timetable as a result.”
