LOUISVILLE, Ky. _ Lamar Jackson floated like a butterfly and stung like a bee.
Down goes Florida State, and their hopes of reaching the College Football Playoff in 2016.
Jackson did more than just fuel No. 10 Louisville to a 63-20 shellacking over the No. 2 Seminoles in front of 55,632 at Papa John's Cardinal Stadium on Saturday afternoon.
On a day honoring late Louisville native Muhammad Ali, Jackson and the Cardinals delivered their knockout blows early and often to hand Jimbo Fisher the worst loss of his career, and was only three points shy from being the worst loss in FSU history.
While both teams still have games against Clemson on the docket _ Louisville heads to Death Valley on Oct. 1 before FSU hosts the Tigers on Oct. 29 _ the Seminoles' hopes of reaching the ACC title game en route to a playoff berth are bleak without help from other members of the conference.
Louisville has the upper hand in the ACC's Atlantic Division race after dealing a major hit to FSU's aspired path to the playoff and Fisher's second national championship.
There was no coming back this time around for the Seminoles, who rallied from a 22-point deficit against Ole Miss on Sept. 5, and a 21-point hole on this same field in 2014.
Jackson put the finishing touches on the blowout by shredding the FSU defense on a 47-yard run 33 seconds into the fourth quarter, capping a day on which he scored four rushing touchdowns and threw for another.
Louisville scored seven rushing touchdowns in all (two by Jeremy Smith and one from Brandon Radcliff), while racking up 531 yards of total offense on the Seminoles.
In a game headlined behind two second-year quarterbacks, Jackson's experience and comfort after starting as a true freshman showed in the biggest victory of his young career.
And his name is in firm position for Heisman Trophy consideration.
FSU's Deondre Francois was no match for Jackson in his third career game and first true road test.
Louisville sacked Francois five times during the game, as he finished with only seven completions for 101 yards and a touchdown to sophomore Auden Tate.
Jackson completed 13 of 20 passes for 216 yards, and added 146 yards on 17 carries to lead the Cardinals.
Florida State fell behind early giving up two rushing touchdowns to Jackson before scoring 10 points to narrow Louisville's lead to 14-10 early in the second quarter.
Then the Seminoles unfolded.
Louisville sacked Francois twice inside two minutes before halftime to regain possession and scored after sophomore cornerback Tarvarus McFadden gambled on an interception that resulted in a 44-yard completion to receiver James Quick.
Jackson scored on a 1-yard scamper three plays later, and Louisville continued with four touchdowns in the second half to bury the Seminoles.
The defeat nearly replaced Florida's 49-0 win over FSU in 1973 as the worst in school history, and was the worst loss for the Seminoles since a 59-20 loss to Oregon in the 2014 Rose Bowl.
