Nick Bosa is the latest San Francisco 49ers star to suffer an injury.
On Sunday, during the first half of the team's matchup with the Arizona Cardinals, Bosa limped off the field before immediately lying down when he got to the sideline. As he limped to the blue tent, he signaled thumbs down.
Nick Bosa signaled a 👎 to someone in the crowd after he was shaken up with a possible injury. pic.twitter.com/82bo7OeDZL
— Alex Tran (@nineralex) September 21, 2025
He then limped back to the team's locker room. Shortly thereafter, the 49ers ruled him questionable to return with a knee injury. After halftime, the team downgraded him to out.
Following the game, 49ers coach Kyle Shanahan said initial tests on Bosa's ACL were negative, but he didn't rule anything out. San Francisco is awaiting results of an MRI.
Kyle Shanahan shares an update on Nick Bosa's knee injury 🤞 pic.twitter.com/z3EDThHkq7
— 49ers on NBCS (@NBCS49ers) September 21, 2025
Bosa is just the latest 49ers star to go down with an injury. Brock Purdy, Jauan Jennings and George Kittle are all out. The team can ill-afford to lose Bosa for long.
The 27-year-old defensive end has opened the season with 11 tackles, two sacks, and a forced fumble. He's vitally important to the 49ers' defense.
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This article was originally published on www.si.com as Nick Bosa Injury: 49ers Star Seen Giving Thumbs Down Before Heading to Locker Room.
