Newcastle United will look to seal their place in the Premier League in front of their own fans.
It was a 0-0 draw on the South Coast that helped post a vital point on the board earlier in the season but United can finish the job now.
Rafa Benitez will warn his side about complacency after the 1-0 win at Leicester City last Friday.
Lee Ryder's prediction
I think Newcastle will take the three points here against a Saints side who are haunted by the prospect of the drop.
Even though Cardiff have it all to do, Southampton know they can still get sucked in and won't be able to relax too much as they focus on taking at least a point.
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But with the tension eased I think United will find their form here at St James' Park and pick up an impressive home win.
Referee (Anthony Taylor)
Last seen in charge of a United game at Arsenal for the 2-0 defeat earlier this month.
Charity bet
United to win at 29/20.
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