Eddie Howe's side will need to get off to a much better start than they did against Manchester City and don't get us started on refereeing decisions and a bit of luck.
Man United should be fresher than Newcastle but make their first appearance on the big stage since December 11, when they beat Norwich, could arguably mean they are also a bit out of practice too in terms of sharpness.
I mentioned the awful series of decisions that Howe's team have endured in the last three matches and you'd like to think Newcastle are due something from the man in the middle.
That said if the Magpies can't improve their woeful defending Man United will see this one as a very winnable encounter.
This one is a hard game to call.
Lee Ryder's prediction
A while back I called the 10 games Newcastle needed to win to stay up.
The first of those matches was the gritty 1-0 victory over Burnley and you'll also find this game against Man United on the list.
The reason for that confidence boils down to the fact we're not talking about one of the great Red Devils teams of the past here.
In fact, when you look at Man United this season they are capable of leaking two or three (or more) in any match so with that Geordie crowd behind Howe's men this should be deemed as another his players can win.
They'll need to tweak the heart of their defence of course and need to eradicate those basic errors, but if they can and the service is better for Allan Saint-Maximin and Callum Wilson, I think they can sneak this one narrowly.
Newcastle vs Manchester United odds with Grosvenor Sport
- Newcastle 6/1
- Draw 18/5
- Manchester United 4/9
(odds subject to change)
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Referee
Craig Pawson (South Yorkshire)
The man who didn't think Ederson's reckless challenge on Ryan Fraser was a penalty. Hopefully, that was a festive rush of blood.
