Steve Bruce stuck with the majority of the team that lost 2-0 to Man City - but recalled Callum Wilson to the starting line-up.
That meant Miguel Almiron dropped down to the bench but Matty Longstaff retained his place in the opening X1 with Sean Longstaff remaining on the bench.
The Magpies went with Federico Fernandez in the heart of defence alongside Ciaran Clark with Fabian Schar making up a three-man central unit.
DeAndre Yedlin remains on the big stage despite interest from Trabzonspor while Matt Ritchie stays in the team.
Dwight Gayle, Andy Carroll offered further attacking options on the bench while Jeff Hendrick was back in the reckoning.
The Magpies faced the Premier League champions knowing they had been handed odds of 10/1.
Newcastle team : Darlow, Yedlin, Schar, Fernandez, Clark, Ritchie, Hayden, Matty Longstaff, Murphy, Joelinton, Wilson
Subs : Dubravka, Lewis, Krafth, Hendrick, S Longstaff, Shelvey, Almiron, Gayle, Carroll
