NEW YORK _ Fueled by a seven-run fourth inning against Chris Sale, the Yankees ran to a 9-2 afternoon victory against the Red Sox.
It was the first game of a day-night doubleheader for the Yankees against their reeling rivals.
Since taking the first three games of a four-game series at Fenway Park, the Boston Red Sox Boston have now dropped six straight games and have plunged to 12.5 games behind the AL East-leading Yanks.
Domingo German (14-2) lasted seven innings and gave up just two solo homers, to Andrew Benintendi (second inning) and Jackie Bradley Jr. (fifth inning).
In four starts this year against the Yankees, the left-handed Sale (5-11) has pitched to nearly a 10.00 ERA.
It was a 1-1 game into the fourth when the Yankees rallied with two out.
Kyle Higashioka's line drive, infield single to third base loaded the bases � the first of six straight hits by the Yanks.
Breyvic Valera followed with an RBI single, Brett Gardner delivered a two-run single and D.J. LeMahieu clubbed his second homer of the day, a three-run shot to right field.
Aaron Judge doubled to chase Sale and Edwin Encarnacion (3-for-4, 2 RBI) greeted Colten Brewer with an RBI single for an 8-1 lead.
As he departed, Sale had some choice words for plate umpire Mike Estabrook. During a mound visit that inning, Estabrook ejected Boston manager Alex Cora, who continued the argument for an extended period.
From the first inning, the Red Sox were riled up about Estabrook's strike zone, starting with a questionable called strike three on J.D. Martinez with a man on second base to end the first inning.
LeMahieu led off the Yankees' first with a homer to right-center, establishing a personal, single-season MLB high with 16 home runs. It was also his fourth leadoff home run of the season.
German struck out seven batters and yielded five hits without walking a batter. Sale was charged with eight runs on nine hits in 3.2 innings, with no walks and four strikeouts.