- Scientists have identified two natural compounds that show promise in reversing brain cell ageing and removing harmful protein buildup, potentially offering a non-drug approach for Alzheimer's disease.
- The compounds, nicotinamide (a form of vitamin B3) and epigallocatechin gallate (an antioxidant found in green tea), restore guanosine triphosphate (GTP) levels, a key molecule for energy production in brain cells.
- Research demonstrated that treating aged nerve cells with these compounds restored GTP levels to those typically seen in younger cells within just 24 hours.
- This restoration of energy levels enabled neurons to regain their critical cleanup function, significantly improving the clearance of amyloid protein clusters, a hallmark feature of Alzheimer's.
- While further studies are required for optimal administration, these findings suggest a promising new strategy for treating age-related cognitive decline and Alzheimer's by supplementing the brain's energy systems.
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