Network Ten will slash jobs including those of some high-profile presenters as it centralises news bulletins.
Weekday Sydney, Brisbane and Perth's news bulletins will be broadcast from Sydney while Adelaide and Melbourne's bulletins will take place in Melbourne.
All state weather presenter positions will be replaced with a national meteorologist under the sweeping changes
There will also be cuts affecting on-air presenters, journalists and operations staff of the Studio 10 morning program, which are yet to be detailed.
The exact number of redundancies has not yet been determined as discussions with staff are just beginning.
Ten's Director of News Content, Ross Dagan, said the decision to restructure was a "very difficult" one to make.
"I want to express my sincere thanks and gratitude to our friends and colleagues who will leave the network," he said.
"It is in no way a reflection of their talent, contribution or passion … there is no doubt they will be missed," said Mr Dagan.
Adelaide news presenter Rebecca Morse has confirmed she is leaving the network amid the sweeping changes and redundancies.
Morse took to Twitter, saying she was proud of her time in the role.
"Sad to confirm the news that I am among those leaving," she said.
"Thank you for your messages of support."
It is understood Adelaide weather reporter Kate Freebairn is also leaving the network amid the changes.
The union representing media workers, the Media, Entertainment and Arts Alliance, described the news as disappointing.
"Unfortunately this is the latest in a number of announcements that undermines journalism and importantly local journalism in this country," said acting media director Adam Portelli.
The Network Ten job losses come following a series of cuts and restructures at other Australian media organisations this year.
A total of 250 jobs will be axed and multiple programs discontinued at the ABC as the national broadcaster deals with $84 million in budget cuts.
The Australian Associated Press newswire was bought by a group of investors and philanthropists in June, saving the business from closure.
News Corp announced a major shake up to its mastheads in May, seeing almost all of its community and regional newspaper titles move to a digital-only format.
Buzzfeed also shut down its Australian news operation earlier this year.
"We have a media landscape that is being hollowed-out and the big losers in that landscape are the readers and viewers ... especially those living in regional areas," Mr Portelli said.
