For the first time since the season-opening Daytona 500, NASCAR will reach 40 entries for a Cup Series race. Along with the usual 36 charted teams, four open entries will take part in NASCAR's longest race on Memorial Day Weekend.
Seven-time NASCAR Cup Series champion and four-time Coke 600 winner Jimmie Johnson will be one of those open entries, driving the No. 84 Legacy Motor Club Toyota. It will also be Johnson's 700th career start.
Trackhouse Racing will enter a fourth car with rising star Connor Zilisch driving the No. 87 Chevrolet, making his second career start in the Cup Series but his first on an oval. Zilisch skipped the most recent Xfinity race at Kansas due to a back injury, but he has been cleared to return to competition this weekend.
Garage 66. (formerly MBM Motorsports) will enter the No. 66 Ford Mustang with Josh Bilicki as the driver while NY Racing Team will enter the No. 44 Chevrolet. No driver has been officially announced for the NY Racing Team entry, but it's likely to be J.J. Yeley.
There are also 40 entries for the NASCAR Xfinity race, which will feature the following Cup stars: William Byron, Austin Dillon, and Chase Briscoe. Of note, Katherine Legge will also be participating after skipping this year's Indy 500 in favor of gaining more stock car experience.
There are 34 entries for the Truck Series, bringing the total to 114 for the three national divisions. Kyle Busch and Ross Chastain are the only full-time Cup drivers in the field, but B.J. McLeod will also be taking part after putting a deal together with Spire Motorsport.
2025 Coca-Cola 600 entry list
| No. | Driver | Team | Manufacturer |
| 1 | Ross Chastain | Trackhouse Racing | Chevrolet |
| 2 | Austin Cindric | Team Penske | Ford |
| 3 | Austin Dillon | Richard Childress Racing | Chevrolet |
| 4 | Noah Gragson | Front Row Motorsports | Ford |
| 5 | Kyle Larson | Hendrick Motorsports | Chevrolet |
| 6 | Brad Keselowski | RFK Racing | Ford |
| 7 | Justin Haley | Spire Motorsports | Chevrolet |
| 8 | Kyle Busch | Richard Childress Racing | Chevrolet |
| 9 | Chase Elliott | Hendrick Motorsports | Chevrolet |
| 10 | Ty Dillon | Kaulig Racing | Chevrolet |
| 11 | Denny Hamlin | Joe Gibbs Racing | Toyota |
| 12 | Ryan Blaney | Team Penske | Ford |
| 16 | AJ Allmendinger | Kaulig Racing | Chevrolet |
| 17 | Chris Buescher | RFK Racing | Ford |
| 19 | Chase Briscoe | Joe Gibbs Racing | Toyota |
| 20 | Christopher Bell | Joe Gibbs Racing | Toyota |
| 21 | Josh Berry | Wood Brothers Racing | Ford |
| 22 | Joey Logano | Team Penske | Ford |
| 23 | Bubba Wallace | 23XI Racing | Toyota |
| 24 | William Byron | Hendrick Motorsports | Chevrolet |
| 34 | Todd Gilliland | Front Row Motorsports | Ford |
| 35 | Riley Herbst | 23XI Racing | Toyota |
| 38 | Zane Smith | Front Row Motorsports | Ford |
| 41 | Cole Custer | Haas Factory Team | Ford |
| 42 | John Hunter Nemechek | Legacy Motor Club | Toyota |
| 43 | Erik Jones | Legacy Motor Club | Toyota |
| 44 | TBA | NY Racing Team | Chevrolet |
| 45 | Tyler Reddick | 23XI Racing | Toyota |
| 47 | Ricky Stenhouse Jr. | Hyak Motorsports | Chevrolet |
| 48 | Alex Bowman | Hendrick Motorsports | Chevrolet |
| 51 | Cody Ware | Rick Ware Racing | Chevrolet |
| 54 | Ty Gibbs | Joe Gibbs Racing | Toyota |
| 60 | Ryan Preece | RFK Racing | Ford |
| 66 | Josh Bilicki | Garage 66 | Ford |
| 71 | Michael McDowell | Spire Motorsports | Chevrolet |
| 77 | Carson Hocevar | Spire Motorsports | Chevrolet |
| 84 | Jimmie Johnson | Legacy Motor Club | Toyota |
| 87 | Connor Zilisch | Trackhouse Racing | Chevrolet |
| 88 | Shane van Gisbergen | Trackhouse Racing | Chevrolet |
| 99 | Daniel Suarez | Trackhouse Racing | Chevrolet |
