More than 300 nurses have committed suicide in just seven years.
During the worst period, one nurse every week was taking their life.
Labour’s shadow health secretary Jonathan Ashworth has called for a Government inquiry into the shocking toll.
Mr Ashworth said: “These are heartbreaking figures and every life lost is a desperate tragedy.”
Between 2011 and 2017, some 305 nurses killed themselves.
Female nurses are more at risk than any other profession, with loneliness, stress and mental ill-health being blamed, according to research.
One victim, Lucy de Oliveira, 22, took her own life two years ago while training in Liverpool.
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Mum Liz, 61, said she blamed the pressures of getting an NHS nursing job for her daughter’s death.
And she claimed younger nurses were afraid to ask for help out of fear mental health issues would become a blot on their professional record.
Liz, of Kidderminster, Worcs, said: “More senior staff say ‘We did it, knuckle down. Be resilient.’
“There’s a bullying and toxic culture which you wouldn’t expect in the NHS. They should be leading the way.”
Laura Hyde, who worked in the emergency department at Derriford Hospital, Devon, and also served as a Royal Navy nurse, took her own life aged 27 three years ago.
Her cousin Liam Barnes said: “Nurses are in a constant cycle of trauma. They are telling parents their children have died. They’re seeing car crash victims and horrific injuries.
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“But they forget they need to look after themselves.”
Laura’s death inspired Liam to launch the Laura Hyde Foundation .
Thousands now visit the website looking for help every week.
The Department of Health said: “The NHS will shortly set out its response to recommendations which will improve mental health support for staff, including access to a dedicated confidential helpline and fast-tracked referral scheme so that anyone struggling gets the help they need.”
