Smoke is filling the sky above the Millennium Mills building as firefighters battle a blaze.
London Fire Brigade is at the scene, near London City Airport, and stated half of a derelict factory is alight.
A statement said: "Ten fire engines and around 70 firefighters have been called to a fire at a derelict factory in Mill Road in Silvertown.
"Around half of one section of the building is currently alight.
"Residents and businesses in the area are advised to keep windows and doors closed as a precaution while firefighters continue to tackle the fire."
The alarm was raised at 6.05pm and the fire was under control by 8.49pm.
The brigade said the location was reported to it as Millennium Mills.
Millennium Mills is an old flour mill on the south side of the Royal Victoria Dock.
It has appeared in numerous films and tv programmes.
Scenes for Ashes to Ashes and Trance were shot at the location.
It has also been used as a setting in music videos for bands such as The Smiths, Arctic Monkeys and Coldplay.
