Arsenal head coach Mikel Arteta has described it as a "massive blow" after potentially losing Lucas Torreira for the rest of the season.
The Uruguayan midfielder sustained the injury in a 2-0 win against Portsmouth at Fratton Park in the fifth round of the FA Cup, following a heavy challenge from Pompey defender James Bolton.
The 24-year-old had to be stretchered off and was seen after the game leaving the stadium in a protective boot and crutches.
Arsenal have confirmed that Torreira is likely to be out for eight to ten weeks as he recovers from the fractured ankle suffered against Portsmouth.
In an update on the official club website, Arsenal posted an statement, which read: 'Sustained fracture to right ankle during Portsmouth (a) on March 2. Still receiving continual assessments.
'Recovery process expected to take between eight to ten weeks.'
But Arteta has given fans hope that Torreira could yet feature again this season.
Speaking at his pre-match press conference ahead of the game against Manchester City on Wednesday, he said: “I wouldn’t like to rule him out.
"Lucas is really keen and would like to play again this season, whether that is realistic or not we will know in the next two or three weeks.
"It depends how the bone is healing and how he is doing with his rehab, but we don't know anything for sure."
