US Secretary of State Mike Pompeo said he was disgusted to see politicians in Britain and the United States continue to support Venezuelan President Nicolas Maduro.
Mr Pompeo was asked about comments made by Labour leader Jeremy Corbyn in support of the President.
US-backed Juan Guaidó declared himself interim president in January, saying President Nicolas Maduro's re-election last year was rigged.
Instead the US back opposition leader Juan Guaido who is trying to lead a revolt against the President.
Speaking alongside Foreign Secretary Jeremy Hunt, Mr Pompeo said: "It is disgusting that leaders in not only the United Kingdom but the United States as well who continue to support the murderous dictator Maduro and it is not in either of our country's best interests for those leaders to continue to advocate on their behalf.
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"No leader from a country with Western democratic values ought to stand behind them."
Jeremy Hunt added: "This is a country where three million people have fled the country, GDP has gone down by 40% in the last four years, people can't access basic medicine, people are rifling through rubbish bags to get food in the streets.
"(Shadow chancellor) John McDonnell describes this as socialism in action and I think people need to draw their own conclusions about what his own plans might be for the UK."
Since 2014 Venezuela has suffered one of the worst economic crisis in their history - which is also among the worst in the world.
It started in 2010 when then-president Hugo Chavez declared an 'economic war' because of food shortages.
"The Venezuelan people have spoken through their constitutional mechanism they have put Juan Guaido as their interim president.
"He is the duly elected leader there and Maduro is on borrowed time.
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Labour spokesperson said in response: "We oppose outside interference in Venezuela, whether from the US or anywhere else: the future of Venezuela is a matter for Venezuelans."
