Michael Conlan will take on Colombian Belmar Preciado at Madison Square Garden's Hulu Theater on March 17.
The Belfast puncher, 28, has made a tradition of fighting in New York since making his professional debut at the world-famous Garden in 2017.
31-year-old Preciado holds a record of 20 victories, two defeats and one draw, with the majority of his pro bouts to date having taken place in his native Colombia.
Conlan goes into a 10-round featherweight bout off the back of three wins in 2019, including over old Olympic rival Vladimir Nikitin.
"I'm honoured to return to the Mecca of Boxing, Madison Square Garden, and fight for the fourth straight St Patrick's Day," Conlan said.
"I know how tough Preciado is, but this fight is a great test as I continue on my path towards becoming a world champion.
"Fighting in New York is very special for me and I look forward to putting on another tremendous show for them this year."
Preciado vowed to belie his underdog status on March 17, saying: "The fans will be there to see Conlan, but mark my words, they will remember me.
"I am more than just another opponent. When I win, I won't be surprised. I am prepared for a hard 10 rounds."
