Coach operator Megabus is restarting some services as England's leisure and hospitality sector prepares to reopen.
Part of its network will run again on July 3, a day before tourist attractions are allowed to welcome back holidaymakers.
Bookings can be made from Thursday but due to social distancing measures there will be reduced capacity, the firm said.
Enhanced cleaning and anti-bacterial stations on board will all be part of the new service, it added.
Megabus, which suspended operations in April, will restart routes serving London, Bristol, Leeds, Sheffield, Newcastle, Sunderland, Middlesbrough, Birmingham, Leicester, Nottingham and Norwich.
The operator, which is part of the Stagecoach Group, said it had put additional safety measures in place to make sure services are "Covid-19 secure".
Drivers will be given masks, visors and gloves, there will be increased filter changing on air conditioning units, and coaches will be deep cleaned before going back on the road, Megabus said.
Managing director Mark Venables said the company is "absolutely delighted" to be able to restart its services.
He said: "We've been carrying out research with our customers and from the overwhelming response we received, we know that people are very keen to get back on board our Megabus services as quickly as possible.
"With the extra safety measures we have to make sure that our services are Covid-19 secure, and with customers following all the Government guidance in place, people can have confidence in travelling with us.
"The timetable we are putting in place will provide access to key cities and towns right across the country. Due to social distancing, there will be reduced capacity on coaches, so we'd urge people to plan ahead and book their journey with us early."
