Matt Hancock is set to host a press conference this evening the day after the Prime Minister's former aide Dominic Cummings launched a scathing attack on him.
Mr Cummings told MPs yesterday that Mr Hancock should of been sacked several times for mistakes he made during the pandemic last year.
The Health Secretary defended himself in the House of Commons earlier today, saying the claims weren't true.
Mr Hancock is expected to appear at 5pm tonight in a press conference to the nation alongside Dr Jenny Harries.
Speaking in the Commons earlier today Mr Hancock said: "These unsubstantiated allegations around honesty are not true.
"I've been straight with people in public and in private throughout."
Answering an urgent question in the Commons, Mr Hancock said: "Every day since I began working on the response to this pandemic last January, I've got up each morning and asked 'What must I do to protect life?'
"That is the job of the Health Secretary in a pandemic.
"We've taken an approach of openness, transparency and explanation of both what we know and of what we don't know."
Mr Cummings accused the Health Secretary of making a "stupid" public pledge to increase testing to 100,000 by the end of April 2020, claiming he then interfered with the building of the Test and Trace system to maximise his chances of hitting his target.
Mr Cummings said: "It was criminal, disgraceful behaviour that caused serious harm,"
But in the Commons, Mr Hancock defended his approach and said: "Setting and meeting ambitious targets is how you get stuff done in Government."
Shadow health secretary Jonathan Ashworth said the allegations made by Mr Cummings are either true - in which case Mr Hancock "potentially stands in breach of the ministerial code" and the principles of standards in public life - or they are false "and the Prime Minister brought a fantasist and a liar into the heart of Downing Street".
Health Select Committee chairman Jeremy Hunt, one of those who questioned Mr Cummings, said they had asked for evidence to be provided to back up the former adviser's claims and until that is produced "those allegations should be treated as unproven".
