Matt Baker says he's self-isolating after a family member showed coronavirus symptoms.
But the County Durham born presenter didn't let quarantine stop him from making his usual appearance on The One Show.
Alex Jones ran things from the studio alone, as her co-presenter appeared via video link.
In the latest example of Covid-19's impact on TV, Matt revealed a member of his family had shown possible symptoms of the virus, to explain his absence from Tuesday night's show.
At the beginning of the BBC programme, Alex, 43, gestured to the empty spot on the sofa next to her and said: "Welcome to Tuesday's live The One Show with me Alex Jones and as you can see, look, the sofa is empty.
"No Matt Baker. Like so many of you, he's working from home today. Matthew, what's going on?"
Matt then appeared from his sofa at home, joined by his pet dog.
He said: "Yes, well I am at home and this is my (pointing to his dog) Alex Jones for tonight and probably for the next two weeks.
"This afternoon we got a phonecall, there's four of us here in this household and one of us has a cough so we're following the Prime Minister's guidelines and now spending the next two weeks self-isolating."
The 42-year-old added: "I kind of expected this to come and feel as ready as we can do. We're more than happy to do our bit and do what's right for everybody, look out for our neighbours."
Alex promised she would "put [him] to use" and Matt appeared throughout the show from his home sofa.
Baker is not the only high-profile TV host affected by coronavirus. Good Morning Britain presenter Susanna Reid is self-isolating after one of her children developed a "persistent cough".
Neither of the presenters are thought to be suffering from any symptoms themselves.
