Manchester United face Manchester City in what promises to be a pulsating contest at Old Trafford.
The two teams go into the match in not their best run of form, with United winning just once in their last six, whilst City have lost two in the same amount of games.
Both teams will be wanting to get a victory over each other, seeing how close they are in the table. United need to win, knowing they would go level on points with Pep Guardiola's team, and a win for City would mean they'd go six points clear ahead of their rivals.
Raphael Varane will be out for the game after injuring his hamstring against Atalanta on Tuesday.
Fellow defender Victor Lindelof missed that game with and is with the United squad, while Paul Pogba is serving a three-match ban.
Manchester City centre-back Aymeric Laporte is suspended following his red card against Crystal Palace.
Here is the team news:
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Bailly, Shaw, Fred, McTominay, Fernandes, Greenwood, Ronaldo.
Manchester City: Ederson, Walker, Dias, Stones, Cancelo, Rodri, Gundogan, De Bruyne, Bernardo Silva, Jesus, Foden.
Greenwood opportunity with Ronaldo
I think the big thing here for United is how the front two are going to play in the absence of Edinson Cavani. As we saw in United's last league match against Spurs, the Uruguayan was absolutely pivotal in getting his team to press high up the pitch and have a good tempo to their play. He even got Ronaldo playing at his best and they looked like a real dangerous partnership upfront.
Against Atalanta though, he didn't start and it was Marcus Rashford leading the forward line alongside Ronaldo. To be honest, I didn't think it worked as well because the England forward seemed a bit lost upfront. He's much better suited as a left-winger.
Mason Greenwood is the one starting for United up front with Ronaldo and it's a move I'm here for. Why? Because Greenwood is a striker. He was deadly up front against Leeds and Southampton and I'm expecting big things from him today.
How will the back three cope?
We all know that this isn't Solskjaer's preferred back three because Varane is out, but as we saw in midweek, Eric Bailly was sensational and he'll need to put in a similar performance if United are to get any positive result from today.
All three of the centre-backs starting today will be familiar with each other's games, having played together last season. They will have to be at their best to stop City from scoring.
Captain Harry Maguire has gone through a bit of a rough patch in recent weeks, but there's arguably no better game to bounce back than the Manchester derby.
Who will win in the derby? Follow our United On My Mind writer Omar Garrick on Twitter to get involved in the discussion and give us your thoughts on the matter in the comments section below.
