Marks & Spencer has said it plans to cut around 7,000 jobs over the next three months across stores, management and its support centre.
The retail giant, which has a workforce of more than 80,000 employees, is expected to start consulting with staff on cuts on Tuesday.
It is not yet known how many jobs will be lost in the various M&S stores in Dublin.
It plans to reduce the number of roles at the retail chain's central support centre, in its regional management and stores between now and November.
The shift is also partly down to an uptake in digital shopping during the coronavirus lockdown.
Marks & Spencer is already axing 950 management and head office roles as coronavirus accelerates an ongoing shake-up.
The announcement was made in July as it warned it was preparing for the "aftershock" of coronavirus, which has "changed shopping habits forever".
The transformation plan, called Never the Same Again, is being stepped up after the disruption of lockdown when the M&S food arm stayed open but its clothing arm was hit hard.
During lockdown, the company said it has learnt to work more flexibly, using the same staff to man both the food aisles and the clothing section of the stores.
"We expect a significant proportion will be through voluntary departures and early retirement. In line with our longstanding value of treating our people well, we will now begin an extensive programme of communication with colleagues," M&S said.
It also expects to create "a number" of new jobs as M&S invests in its online capacity.
Bosses previously said the transformation will help move the company to "a leaner, faster retail management structure" as it accelerates its online presence.
