Ole Gunnar Solskjaer makes 11 changes to the Manchester United side that was beaten by West Ham in the Carabao Cup in midweek and reverts back to the team that beat the Hammers 2-1 last Sunday.
That means Cristiano Ronaldo is back to lead the United attack, with the returning Edinson Cavani on the bench.
For Villa, Dean Smith makes one change to the team that beat Everton 3-0 last weekend.
Axel Tuanzebe is unable to feature against his parent club so Kortney Hause comes in at Old Trafford for his first Premier League start of the season.
Manchester United confirmed XI: De Gea, Wan-Bissaka, Varane, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Pogba, Ronaldo.
Subs: Heaton, Lindelof, Martial, Lingard, Dalot, Cavani, Sancho, Matic, Van de Beek.
Aston Villa XI: Martinez, Cash, Konsa, Hause, Mings, Targett, Ramsey, Luiz, McGinn, Ings, Watkins.
Subs: Steer, Buendia, Traore, Young, Nakamba, El Ghazi, Chukwuemeka, Archer, Bogarde.
