Mason Greenwood, Anthony Martial and Dan James all start for Manchester United against AC Milan.
United are without Marcus Rashford and Edinson Cavani for their crucial Europa League last-16 first-leg clash at Old Trafford.
In their absence, Martial leads the line and is supported by Greenwood, James and Bruno Fernandes.
Rashford was forced off during the second half of United’s win at rivals Manchester City and he and Cavani are not in the squad.
Paul Pogba's thigh injury keeps him out, having been missing for a month. David de Gea remains absent following the birth of his daughter, so Dean Henderson keeps his place.
For AC Milan, on-loan Mancehster United defender Diogo Dalot starts against parent club.
Chelsea defender Fikayo Tomori is also named in the Milan team but Zlatan Ibrahimovic is out with a thigh injury so does not face his former club.
Manchester United line-up: Henderson, Wan-Bissaka, Bailly, Maguire, Telles, McTominay, Matic, James, Fernandes, Martial, Greenwood.
Subs: Grant, Bishop, Lindelof, Fred, Diallo, Shaw, Williams, Tuanzebe, Shoretire.
AC Milan line-up: Donnarumma, Calabria, Tomori, Kjaer, Dalot, Krunic, Meite, Kessie, Saelemaekers, Leao, Diaz.
Subs: Tatarusanu, A Donnarumma, Castillejo, Tonali, Kalulu, Tonin, Gabbia.
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