Manchester United are looking to build on their up-turn in form in the Premier League, as well as their convincing win in the Champions League, when they take on Wolverhampton Wanderers at Old Trafford.
Manchester City travel to Cardiff City, where they were winners in a feisty FA Cup contest last season, and Liverpool host Southampton.
Crystal Palace are looking to make it back-to-back wins when they host Newcastle United and Leicester City will want to bounce-back against Huddersfield Town after losing heavily against Bournmouth, who travel to Burnley.
Follow all the action in the live blog below:
Live Updates
16:50
Lots of goals in the 3pm kick offs, City have 5, Burnley have 4, Liverpool have 3 time is running out, how many last minute goals will we get?
16:33
Crystal Palace vs Newcastle
Poor developments at Selhurst Park:
16:31
Crystal Palace vs Newcastle
You heard him Max!
16:22
Burnley vs Bournemouth
Burnley 2 - 0 Bournemouth
Joe Hart keeping Burnley two goals to the good at Turf Moor, he's made a few good saves today and denied Bournemouth a way back into this game
16:21
The goals aren't flowing as frequently as they did in the first half, one more for Huddersfield and Manchester United and my Super6 is looking quite promising!
16:17
Manchester United vs Wolves
Mark Critchley gives us his thoughts on that Wolves equaliser:
"Questions over Luke Shaw, who failed to cut out Helder Costa's cross despite driving him all the way to the byline. Costa still did well to find Raul Jimenez, in fairness, and Jimenez makes the right decision by cutting back for Joao Moutinho rather than taking on the chance himself. On the balance of play, 1-1 is a fair scoreline."
16:10
Cardiff vs Manchester City
Cardiff 0 - 3 Man City
Injury at Cardiff, Lee Peltier looks to have done some damage to his shoulder in a tussle with Leroy Sane, he goes off the pitch looking in some discomfort
16:07
Leicester vs Huddersfield
Leicester 1 - 1 Huddersfield
End to end stuff at the King Power Stadium, don't expect this deadlock to last much longer, more goals are surely to come.
16:06
We're back underway, stay tuned for all the goals in the next 45 minutes of Premier League action
16:03
Manchester United vs Wolves
Fred gets his first goal for Man Utd, his first celebration is unique as well:
16:02
Liverpool vs Southampton
Liverpool lead 3-0 at half time, here's a look at some of the match action:
