A blockbuster derby fixture over two legs will decide who reaches March’s final at Wembley.
After a 2-0 defeat to Arsenal and a 0-0 draw with Wolves in the FA Cup, the Red Devils are expected to field their strongest available side with a trip to Wembley at stake. Manchester City are also expected to field a strong team after Pep Guardiola shuffled his pack during the 4-1 FA Cup win over Port Vale on Saturday. Follow live coverage below:
Full line-ups and team news will be dropping shortly, and we can expect near-full-strength XIs from both sides. In the meantime, here's the latest from the United camp today:
Both sides name strong starting XIs, then, as expected. United bring in Jesse Lingard, Marcus Rashford, Fred, Aaron Wan-Bissaka and Phil Jones after a goalless draw against Wolves in the FA Cup third round on Saturday.
City also rested several key players in their third round tie against Port Vale, so Pep Guardiola makes eight changes tonight. Neither team are taking this lightly.
City will be strong favourites to reach the final over two legs, but last month's 2-1 defeat against their city rivals remains fresh in the memory. United's form has been inconsistent since then, but they have proven themselves capable of competing against a team described by Ole Gunnar Solskjaer as "the best in the world".
"The game we lost here in the league we played one of the best first halves," Pep Guardiola has said in the buildup to tonight's game. "We played incredible, but played 10 or 15 minutes bad in the second half and they recovered.
"We conceded a few counter-attacks and in just two or three seconds they were in the box. We saw how fast they are, how they run on the counter-attack, how solid and how aggressive.
"A top club like United you can lose, but we beat them more times than we lose."
Solskjaer, meanwhile, has insisted results over the last few weeks mean nothing when it comes to the Manchester Derby.
"In a derby it's about adrenalin and atmosphere," he said.
"I admire Pep. They've raised the bar so much it's something to aim for. They're back winning games and confident, but form goes out of the window [in a derby]."
Ole Gunnar Solskjaer speaking to Sky Sports: "If we create as many chances as we did last month [against City] I will be happy. We play a good team, hopefully we can see the same. It's a young team, loads of energy.
"We have injuries at the back, Harry Maguire is out and Phil Jones is ready to come in. We have given the young lads a good chance here tonight. It's probably the biggest game they have played.
"That's the way to learn, you don't know until they get a chance in a game like this and I'm sure they will enjoy it. Every game is big for Manchester United."
Pep Guardiola speaking to Sky Sports: "They have an incredible team on the counter-attack, one of the best in the world. We have to control that situation or it will be impossible to reach the final.
"We will have lots of passes and hurt them at the right times. Two good teams fighting for the second title of the season."
City start strongly, knocking the ball around confidently at the back before Walker is set away down the right. He looks for De Bruyne in the middle but the Belgian can't quite get it under control.
James is picked out on the right and whips a cross towards Greenwood in the middle. Otamendi is in the way, but United are showing some promising attacking intent early on.
Greenwood skips down the right flank and slips a pass through to Rashford, who bursts past Otamendi and drills the ball into the middle. Fernandinho makes a crucial intervention to get it clear.
A long ball up to Greenwood is nodded into the path of Rashford, who tries to beat Fernandinho in the box but can only win a corner. The set piece is taken short and eventually whipped into the box by Fred, but his cross evades everyone.
A long spell of City possession eventually comes to an end with a loose pass from Mendy. United look well organised at the moment, and they're posing a persistent threat on the break through Greenwood and Rashford.
Manchester City: Bravo, Walker, Otamendi, Fernandinho (C), Mendy, Rodrigo, Gundogan, Mahrez, De Bruyne, Bernardo, Sterling
Subs: Ederson, Jesus, Aguero, Silva, Cancelo, Foden, E Garcia
Prediction
Manchester United stunned City with derby victory at the Etihad in December, but the reigning champions should have too much quality against an injury-struck Red Devils side on Tuesday.
Manchester United 1-2 Manchester City
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