Marcus Rashford’s goal, along with David de Gea’s brilliance, secured a win against Tottenham last week which moved United level on points with Arsenal in the table.
Brighton performed valiantly in last week’s loss against Liverpool, and the Seagulls are seven points clear of the relegation zone in 13th; they also memorably beat United 3-2 in August.
Good afternoon and welcome to The Independent's live coverage of today's 3pm kick-offs across the Premier League.
Team news will be announced across the country at 2pm, which we'll bring you as soon as it drops for all six games that start mid-afternoon.
With Manchester City not playing until Sunday, Liverpool can put the pressure on as they take on Crystal Palace at Anfield, while Manchester United are also at home with Ole Gunnar Solskjaer looking to continue his winning streak against Brighton and Hove Albion.
Newcastle United need a win at home to move out of the relegation zone as they face Cardiff City, the team directly above them, while Bournemouth and West Ham meet in a mid-table encounter at the Vitality Stadium. That’s not the only clash on the south coast as resurgent Southampton host struggling Everton, and Watford take on Burnley at Vicarage Road.
No Marko Arnautovic for the visitors at the Vitality Stadium, with the Austrian's departure to China perhaps moving closer by the day despite West Ham's resolve to keep him.
Andy Carroll starts in his absence on the South Coast, while Callum Wilson (another player in the rumour mill this January) returns for Bournemouth.
Victorious with ten men at the King Power last weekend, Ralph Hasenhuttl's Southampton will look to build as they enter a crucial period with a number of games against those around them.
Everton are their opponents today. Marco Silva's team could end the day in seventh if results go their way...
It is two years since the unfortunate passing of Graham Taylor, and should Javi Gracia and Watford win this afternoon the Spaniard is planning a special tribute to the club's greatest manager.
James Milner starts at right-back for Liverpool today, with Trent Alexander-Arnold sidelined.
It has been a good day for Alexander-Arnold, however, with the 20-year-old has today putting pen-to-paper on along-term deal at Anfield to commit his future to his boyhood club.
News from Old Trafford, and it will be a late enforced change for Manchester United with Luke Shaw taken ill. Diogo Dalot replaces him in the starting lineup, with Ashley Young presumably switching to left-back.
Manchester United vs Brighton kicks off at 3:00pm (GMT) on Saturday 19th January.
Where can I watch it?
The match will not be shown live on TV or online in the UK.
Independent Sport will keep you up to date with all the goals as they fly in via our live blog.
Highlights will be shown at 10:20pm on BBC One.
Marcus Rashford celebrates opening the scoring at Wembley Stadium (Getty Images)
Player to watch…
Marcus Rashford: The 21-year-old has flourished since Solskjaer took charge in mid-December. Currently preferred to Romelu Lukaku up front, Rashford finished superbly last week against Tottenham, and will be eager to add to his seven Premier League goals on Saturday afternoon against a Brighton side known for their defensive resilience.
David de Gea celebrates closing out the win at Wembley Stadium (Getty)
