We all know how much Duncan Ferguson used to revel in making United suffer.
And he'll be in the dug out at Old Trafford once again.
But will that be enough to build on last weekend's Big Dunc inspired victory? We asked our Everton correspondent Phil Kirkbride for his verdict.
Win, lose or draw?
Draw. On the back of a rousing win over Chelsea, Everton will once again be highly motivated under caretaker boss Duncan Ferguson and will come away from Old Trafford with a point. The draw is 11/4 with thepools.com.
Who's a good bet for 1st scorer?
Richarlison. The man who is in form. He is 7/1 to be first scorer. That's a great price.
Who's on the naughty step?
If Ashley Young is in the team then expect him to be booked for a sixth time this season.
Who's on pens?
Gylfi Sigurdsson. He's a big 11/1 to score first and 15/4 to score at any time.
Will the Blues keep a clean sheet?
Yes. Everton restricted Chelsea, despite the visitors having 70% of possession, to very few meaningful shots at Goodison last week. Mateo Kovacic's volley did beat Jordan Pickford but the Everton keeper was rarely stretched other than that. Both teams To Score 'No' is a big Evens call.
