Harry Maguire has returned to Manchester United's team against Newcastle after he was an unused substitute against AZ Alkmaar in midweek.
Axel Tuanzebe, Ashley Young, Scott McTominay, Andreas Pereira and Marcus Rashford have also come into the starting line-up from the midweek game in the Netherlands.
United are targeting a first away Premier League win since February on Tyneside and they haven't won away from home in all competitions since March's memorable win against Paris Saint-Germain.
The Reds' torrid run of form away from Old Trafford has included defeats by West Ham, Everton, Barcelona, Arsenal and Wolves twice, and they have not scored more than once in any away game since that PSG victory.
In Newcastle, though, United are facing a team in far worse form than them and failure to collect maximum points here will be deemed a failure.
United team vs Newcastle
Starting XI: De Gea; Dalot, Tuanzebe, Maguire, Young; Fred, McTominay; Pereira, Mata, James; Rashford
Subs: Romero, Rojo, Williams, Matic, Chong, Gomes, Greenwood
