Manchester United manager Ole Gunnar Solskjaer expects Victor Lindelof to be fit for the derby on Saturday.
Lindelof missed United's 2-2 Champions League draw with Atalanta on Tuesday due to a training ground injury he sustained on Monday, however the Sweden captain was included in the national team squad for their upcoming World Cup qualifiers against Georgia and Spain.
Fellow centre-back Raphael Varane is sidelined for a month with a hamstring strain and Paul Pogba is still suspended following his expulsion in the 5-0 hammering by Liverpool. Eric Bailly is set to start if Solskjaer retains a back three.
"With all the technology now, you expect him to be out for four or five weeks with the scans we've seen of him," Solskjaer said of Varane. "It's a blow for us. Raphael has come in and been really, really influential. Eric came in last time and was excellent. That's why we have a big squad and cope with absentees.
"Lindelof? He's still a doubt, but hopefully, he can come back in tomorrow and say that he's ready. I would expect him to be ready, to put it that way, but I can't promise you."
United host City in their first home game since the 5-0 thrashing by Liverpool and they have responded to that dark day by beating Tottenham and earning a creditable draw with Atalanta.
Solskjaer has presided over four victories over Manchester City and United are unbeaten in their last four Premier League derbies.
"We've moved on from [Liverpool]. Of course, it's going to be in the history books but we've had a good week, with good results away from home, difficult games and the mindset is positive.
"We've got to go in this game believing we can do good things. It's a local derby and everyone knows what's at stake.
"It's a special one, the last time we had a Manchester derby with fans in the stadium the atmosphere was electric, I think everyone will still remember that one probably more so than any dark moments we had.
"When Scott [McTominay] scored that goal in the extra-time it was a special moment. It's a one-off game, it's one of those you have to start on the front foot, start ready, because a lot of it depends on who gets on the front foot."
"The team is very close together and they know they need each other, it's team bonding and the team spirit is important. We've got a great canteen up here but are probably fed up with Mike's food!"
